Australia number eight David Pocock has recovered from his neck injury in time to face England at Twickenham on Saturday.
Pocock sustained the injury against Italy last weekend to place his involvement in the Cook Cup showdown in doubt, although England boss Eddie Jones on Monday accused the Wallabies of smoke and mirrors.
"I hear this every time we play Australia - Pocock's not going to be fit. So when I heard it I thought: 'here we go again.' You know those merry-go-rounds? It's a bit like that," Jones said.
England view Pocock as the greatest threat to their bid to record a sixth successive win in the fixture due to his breakdown expertise, with flanker Brad Shields describing the 30-year-old as the game's most accomplished fetcher.
In an unexpected call by head coach Michael Cheika, Kurtley Beale has been left out of the matchday 23 entirely. Since making his debut in 2009, Beale has been an ever-present for Australia when fit.
Matt Toomua continues at fly-half with Bernard Foley picked in the unusual position of inside centre, while scrum-half Will Genia becomes the 10th Wallaby to join the rank of Test centurions.
— Qantas Wallabies (@qantaswallabies) November 22, 2018
Australia team to play England
Forwards: 1 Scott Sio, 2 Tolu Latu, 3 Sekope Kepu, 4 Izack Rodda, 5 Adam Coleman, 6 Jack Dempsey, 7 Michael Hooper (Captain), 8 David Pocock
Backs: 9 Will Genia, 10 Matt To'omua, 11 Jack Maddocks, 12 Bernard Foley, 13 Samu Kerevi, 14 Dane Haylett-Petty, 15 Israel Folau
Replacements: 16 Tatafu Polota-Nau, 17 Jermaine Ainsley, 18 Allan Alaalatoa, 19 Rob Simmons, 20 Ned Hanigan, 21 Pete Samu, 22 Nick Phipps, 23 Sefa Naivalu