Sean O'Brien will make his first Test start in almost a year when Ireland host Argentina in Dublin on Saturday.
Ireland have rolled out all their big guns to take on the Pumas, with boss Joe Schmidt restoring his first-choice XV following last weekend's 54-7 win over Italy in Chicago.
Leinster and British and Irish Lions flanker O'Brien has not featured for Ireland since the 28-19 win over Argentina in Dublin on November 25, 2017.
O'Brien missed Ireland's Six Nations Grand Slam triumph after hip trouble, then the summer tour to Australia with a shoulder concern.
Jordan Larmour keeps his place at full-back after his stellar hat-trick against Italy, with Rob Kearney unfit through shoulder trouble.
Bundee Aki partners Robbie Henshaw in the centres, with Garry Ringrose appearing to have missed out after picking up a knock.
Rory Best returns to captain Ireland, with front-line stars Johnny Sexton, Keith Earls and Robbie Henshaw returning in the back line.
Cian Healy and Tadhg Furlong are restored in a potent front row, with James Ryan and Iain Henderson linking up to form Ireland's likely first-choice locking pair.
O'Brien is joined in the back row by fellow Lions 2017 tourists Peter O'Mahony and CJ Stander.
Ireland head coach Schmidt confirmed both Kearney and Ringrose missed out through injury.
Schmidt hopes Kearney will be fit in time to face the All Blacks next weekend, while Ringrose is still trying to overcome the final effects of a minor hip complaint.
"Rob Kearney was involved in the session today and ran really well," said Schmidt.
"Garry (Ringrose) didn't train on Tuesday, he had a pinch. He could have played on Saturday but we didn't want to take any risks.
"This way just gives us a little more time to make sure he's ready for training on Monday for the following week. Garry just got a bang on the hip. He's actually recovered from that mostly.
"But at the start of the week you're just trying to make sure everything is as cohesive as possible."
— Irish Rugby (@IrishRugby) November 8, 2018
Ireland team to play Argentina
Forwards: 1 Cian Healy (Leinster), 2 Rory Best (Captain, Ulster), 3 Tadhg Furlong (Leinster), 4 Iain Henderson (Ulster), 5 James Ryan (Leinster), 6 Peter O'Mahony (Munster), 7 Sean O'Brien (Leinster), 8 CJ Stander (Munster)
Backs: 9 Kieran Marmion (Connacht), 10 Jonathan Sexton (Leinster), 11 Jacob Stockdale (Ulster), 12 Bundee Aki (Connacht), 13 Robbie Henshaw (Leinster), 14 Keith Earls (Munster), 15 Jordan Larmour (Leinster)
Replacements: 16 Sean Cronin (Leinster), 17 Jack McGrath (Leinster), 18 Andrew Porter (Leinster), 19 Devin Toner (Leinster), 20 Dan Leavy (Leinster), 21 Luke McGrath (Leinster), 22 Joey Carbery (Munster), 23 Andrew Conway (Munster)