Tadhg Beirne will have the chance to kick-start his Test career after winning selection in a much-changed Ireland team to face the United States on Saturday.
Garry Ringrose is the sole survivor from Ireland's stunning 16-9 win over New Zealand last weekend as head coach Joe Schmidt has made 14 changes for the USA's visit to Dublin.
Munster lock Beirne will earn his fourth cap and second start, while his provincial mate Sam Arnold could make his Test debut off the bench.
John Cooney will make his full debut at scrum-half, with Joey Carbery taking the reins at 10.
Beirne is quickly advancing his Ireland claims after trading Scarlets for Munster in the summer, and has already put some heat on senior locks like Iain Henderson and Devin Toner.
Toner excelled in Ireland's first-ever victory over New Zealand on home soil though, to reassert his status as starting lock, alongside the ever-imperious Leinster youngster James Ryan.
Henderson will be itching to prove a point given he is starting against the USA then, having not made the starting line-up for the All Blacks win.
Head coach Schmidt confirmed he had always planned to make wholesale changes for the USA clash, then hailed lock Beirne's swift progress in the Ireland set-up.
"This was always part of the plan to make the changes, the two games book-ended the series and it's a chance to look at all of the 43 players across the four matches," said Ireland boss Schmidt.
"Tadhg (Beirne) has slotted in so well, coming off the bench a couple of times in Australia in the summer, and bedding in as part of the broader squad.
"And I thought Iain Henderson came on and did really well last week against New Zealand.
"Tadhg has a really instinctive feel for the game; his running lines, his ability to get into the right defensive positions. Those things are a little bit intuitive, and it's great to coach a guy who tends to know where to be most of the time."
— Irish Rugby (@IrishRugby) November 22, 2018
Ireland team to play USA
Forwards: 1 Dave Kilcoyne (Munster), 2 Niall Scannell (Munster), 3 Finlay Bealham (Connacht), 4 Tadhg Beirne (Munster), 5 Iain Henderson (Ulster), 6 Rhys Ruddock (Captain, Leinster), 7 Jordi Murphy (Ulster), 8 Jack Conan (Leinster)
Backs: 9 John Cooney (Ulster), 10 Joey Carbery (Munster), 11 Darren Sweetnam (Munster), 12 Stuart McCloskey (Ulster), 13 Garry Ringrose (Leinster), 14 Andrew Conway (Munster), 15 Will Addison (Ulster)
Replacements: 16 Rob Herring (Ulster), 17 Cian Healy (Leinster), 18 John Ryan (Munster), 19 Quinn Roux (Connacht), 20 Josh van der Flier (Leinster), 21 Luke McGrath (Leinster), 22 Ross Byrne (Leinster), 23 Sam Arnold (Munster)*
* Denotes uncapped player