Ireland centre Robbie Henshaw has been ruled out of Saturday’s autumn international against South Africa and will be replaced by Stuart McCloskey.
Leinster player Henshaw was absent from training on Friday morning due to a hamstring issue.
Ulster’s McCloskey will step up from the bench to partner Garry Ringrose in midfield and win his seventh Test cap.
Head coach Andy Farrell has added Jimmy O’Brien to his replacements for the visit of the Springboks.
Ireland team to play South Africa
Forwards: 1 Andrew Porter (Leinster), 2 Dan Sheehan (Leinster), 3 Tadhg Furlong (Leinster), 4 Tadhg Beirne (Munster), 5 James Ryan (Leinster), 6 Peter O’Mahony (Munster), 7 Josh van der Flier (Leinster), 8 Caelan Doris (Leinster)
Backs: 9 Conor Murray (Munster), 10 Johnny Sexton (CAPTAIN, Leinster), 11 Mack Hansen (Connacht), 12 Stuart McCloskey (Ulster), 13 Garry Ringrose (Leinster), 14 Robert Baloucoune (Ulster), 15 Hugo Keenan (Leinster)
Replacements: 16 Rob Herring (Ulster), 17 Cian Healy (Leinster), 18 Finlay Bealham (Connacht), 19 Kieran Treadwell (Ulster), 20 Jack Conan (Leinster), 21 Jamison Gibson Park (Leinster), 22 Joey Carbery (Munster), 23 Jimmy O'Brien (Leinster)