Gregor Townsend has included the uncapped trio of Sam Skinner, Sam Johnson and Blade Thomson in his Scotland squad for the autumn internationals.
Exeter second-rower Skinner is a former England youth international while Scarlets number eight Thomson has represented New Zealand's Under-20s.
They join Glasgow centre Johnson in the 40-man group named ahead of next month's clash with Wales in Cardiff and three Murrayfield Tests against Fiji, South Africa and Argentina.
Scotland's most-capped player Ross Ford has won a recall as he looks to build on his 110 appearances for the national team.
But Stuart Hogg, Zander Fagerson, Richie Gray, Duncan Taylor and Tim Swinson miss out through injury.
Head coach Townsend said: "We now begin the last 12 months of our preparations for Rugby World Cup 2019 with four Test matches in four weeks, a similar challenge to the one we'll face in Japan.
"We've named a 40-man group for this campaign, which highlights the quality of player that is now available to us and the competition for places.
"It also enables us to welcome more players into our training environment and hopefully give a few more players a taste of Test match rugby.
"It's going to be an exciting year for the squad but our primary focus is fixed on performing well against Wales - familiar opponents who have already recorded a win against us this year."
Thomson and Skinner are eligible for Scotland through family connections, Thomson through his Wishaw-born paternal grandfather Robert, while Skinner's father Peter hails from Ayr.
Skinner, 23, has previously been involved in the Scottish Exiles programme as a teenager before being called up for England Under-20s.
He played a prominent role as Exeter won the Premiership title for the first time in 2017 and finished as runners-up in last year's final.
Thomson, 27, arrived in west Wales from Super Rugby side Hurricanes, having represented New Zealand Under-20s and the Maori All Blacks, and has been a stand-out performer for Scarlets in his debut Guinness PRO14 season.
Australian-born Johnson is eligible for Scotland on residency grounds, having joined Glasgow in the summer of 2015.
— Scottish Rugby (@Scotlandteam) October 17, 2018
Scotland squad for autumn internationals
FORWARDS: Alex Allan (Glasgow Warriors), Simon Berghan (Edinburgh), Magnus Bradbury (Edinburgh), Fraser Brown (Glasgow Warriors), Allan Dell (Edinburgh), David Denton (Leicester Tigers), Matt Fagerson (Glasgow Warriors), Ross Ford (Edinburgh), Grant Gilchrist (Edinburgh), Jonny Gray (Glasgow Warriors), Rob Harley (Glasgow Warriors), Murray McCallum (Edinburgh), Stuart McInally (Edinburgh), Willem Nel (Edinburgh), Gordon Reid (London Irish), Jamie Ritchie (Edinburgh), Sam Skinner (Exeter Chiefs)*, Blade Thomson (Scarlets)*, Ben Toolis (Edinburgh), George Turner (Glasgow Warriors), Hamish Watson (Edinburgh), Ryan Wilson (Glasgow Warriors)
BACKS: Alex Dunbar (Glasgow Warriors), Dougie Fife (Edinburgh), Chris Harris (Newcastle Falcons), Adam Hastings (Glasgow Warriors), George Horne (Glasgow Warriors), Pete Horne (Glasgow Warriors), Sam Johnson (Glasgow Warriors)*, Huw Jones (Glasgow Warriors), Lee Jones (Glasgow Warriors), Blair Kinghorn (Edinburgh), Greig Laidlaw (Clermont Auvergne), Sean Maitland (Saracens), Byron McGuigan (Sale Sharks), Ali Price (Glasgow Warriors), Henry Pyrgos (Edinburgh), Finn Russell (Racing 92), Matt Scott (Edinburgh), Tommy Seymour (Glasgow Warriors)
*denotes uncapped player