Full-back Stuart Hogg is the only player retained in Scotland's starting line-up for their rematch with France at Murrayfield on Saturday.
Head coach Gregor Townsend has opted to recall several experienced players, with scrum-half Greig Laidlaw selected to captain the team, and stand-off Finn Russell and wings Sean Maitland and Tommy Seymour also coming in.
Blade Thomson will make his long-awaited Scotland debut after he missed the autumn internationals and Six Nations with concussion.
New Zealand-born Thomson, who qualifies to play for Scotland through his paternal grandfather, will be joined in the back-row by Hamish Watson and Ryan Wilson.
Scott Cummings has been handed a first start after coming off the bench at Allianz Riviera for his international debut and will combine with Sam Skinner in the second row.
Peter Horne and Chris Harris form the centre partnership, with props Gordon Reid and Willem Nel either side of hooker George Turner.
Townsend told scottishrugby.org: "Our first outing of the season was a disappointment and not reflective of the hard work our players have put in over the past two months.
"France are a very dangerous side if you give them space and quick ball to play, which is what we allowed to happen on too many occasions last week. Our focus all week has been to remedy this and also create much more from our attacking game.
"It was a stark reminder of how tough things can be at international level if our standards slip.
"We expect our players to show a much truer picture of themselves this Saturday."
Scotland, whose best World Cup finish was fourth in 1991, have been selected in Pool A alongside Ireland, Russia, Samoa and hosts Japan for this year's tournament.
After Saturday's second meeting with France, Townsend's men face a home and away double-header against Georgia before their World Cup campaign begins against Ireland on September 22 in Yokohama.
— Scottish Rugby (@Scotlandteam) August 21, 2019
Scotland team to play France
Forwards: 1 Gordon Reid (Ayrshire Bulls), 2 George Turner (Glasgow Warriors), 3 Willem Nel (Edinburgh), 4 Scott Cummings (Glasgow Warriors), 5 Sam Skinner (Exeter Chiefs), 6 Ryan Wilson (Glasgow Warriors), 7 Hamish Watson (Edinburgh), 8 Blade Thomson (Scarlets)*
Backs: 9 Greig Laidlaw (CAPTAIN, Clermont Auvergne), 10 Finn Russell (Racing 92), 11 Sean Maitland (Saracens), 12 Pete Horne (Glasgow Warriors), 13 Chris Harris (Gloucester), 14 Tommy Seymour (Glasgow Warriors), 15 Stuart Hogg (Exeter Chiefs)
Replacements: 16 Grant Stewart (Glasgow Warriors)*, 17 Allan Dell (London Irish), 18 Simon Berghan (Edinburgh), 19 Grant Gilchrist (Edinburgh), 20 John Barclay (Edinburgh), 21 George Horne (Glasgow Warriors), 22 Rory Hutchinson (Northampton Saints), 23 Blair Kinghorn (Edinburgh)
* Denotes uncapped player