Gareth Anscombe has retained the Wales fly-half role ahead of Dan Biggar for Saturday's Under Armour Series clash against Australia.
Anscombe impressed during Wales' 21-10 victory over Scotland last weekend, when Northampton number 10 Biggar was unavailable as England-based players were ruled out because that game fell outside World Rugby's autumn Test window.
Biggar and his fellow British and Irish Lions back - Saracens wing Liam Williams - are on the bench, with the Welsh Rugby Union announcing three changes as head coach Warren Gatland hands starts to Worcester wing Josh Adams, Exeter prop Tomas Francis and Ospreys lock Adam Beard.
Gatland said: "With selection, we wanted some continuity and to be consistent, but also mindful there are a number of players who did really well for us in the summer, and they need to be rewarded and have their opportunity.
"Adam impressed in the summer, as did Josh, and they deserve the chance to start.
"There is a really good balance to the team, a lot of competition, which is exactly what we wanted.
"The bench is packed with quality and experience, and it will be great to see them have an impact on Saturday.
"We were pleased to get a good opening win under our belts last weekend, and this Saturday is all about building on that."
Adams replaces Luke Morgan, who made his Test debut against Scotland, while Francis takes over from Dillon Lewis and Beard is preferred to Cory Hill as captain Alun Wyn Jones' second-row partner.
Lewis and Hill are among the replacements, with a powerful Wales bench also including fit-again Cardiff Blues flanker Ellis Jenkins, who captained Wales to a win against South Africa in Washington DC earlier this year.
Adams, a Test newcomer during last season's Six Nations Championship, has maintained impressive form for Worcester, with highly rated Beard also gaining a golden opportunity as Wales target a first win against Australia since 2008.
If Wales can end a 13-Test losing run against the Wallabies, it would give them a seventh successive victory this year and secure a longest unbeaten sequence since the 2004-05 season.
— Welsh Rugby Union (@WelshRugbyUnion) November 8, 2018
Wales team to play Australia
Forwards: 1 Nicky Smith, 2 Ken Owens, 3 Tomas Francis, 4 Adam Beard, 5 Alun Wyn Jones (Captain), 6 Dan Lydiate, 7 Justin Tipuric, 8 Ross Moriarty
Backs: 9 Gareth Davies, 10 Gareth Anscombe, 11 Josh Adams, 12 Hadleigh Parkes, 13 Jonathan Davies, 14 George North, 15 Leigh Halfpenny
Replacements: 16 Elliot Dee, 17 Rob Evans, 18 Dillon Lewis, 19 Cory Hill, 20 Ellis Jenkins, 21 Tomos Williams, 22 Dan Biggar, 23 Liam Williams