Ospreys wing Luke Morgan will make his Wales debut in Saturday's Under Armour Series opener against Scotland at the Principality Stadium.
Morgan, Wales' record try-scorer on the world sevens circuit, returned to Ospreys colours this season following a six-year stint in rugby's abbreviated format and made a first Guinness PRO14 appearance in September.
Elsewhere, there is a recall for Ospreys flanker Dan Lydiate, whose last international appearance was 11 months ago, with lock Alun Wyn Jones captaining a team that contains seven British and Irish Lions Test players.
Wales assistant coach Rob Howley said: "It's great to reward players on form, and we're looking forward to seeing Luke make his debut on the wing.
"He's come through the sevens system, he will bring a point of difference to the squad and it's a great opportunity for him."
Dragons forward Cory Hill partners Jones in the second row, and Cardiff Blues back Gareth Anscombe is handed the fly-half role for only his fourth start in that position from 19 Test appearances.
Centre Jonathan Davies, Lions player of the series against New Zealand last year, is back in midfield following his recovery from a serious foot injury suffered during the 2017 autumn Tests.
There are also opportunities for props Nicky Smith and Dillon Lewis, with uncapped Blues fly-half Jarrod Evans on the bench.
Wales are without England-based quartet Liam Williams, Dan Biggar, Josh Adams and Tomas Francis as the Scotland game falls outside World Rugby's autumn Test window and they must remain with their clubs.
But head coach Warren Gatland, who is now back at the Wales camp after returning to New Zealand last week - following the death of his father - can still field a side comprising almost 650 caps of international experience.
Howley added: "We are excited to kick off our autumn campaign on Saturday, and it was great to welcome Warren back yesterday.
"Warren has been in constant dialogue with us over the past week, and we have selected a very strong squad for this weekend.
"We have created good strength in depth, especially from the summer, and have a nice balance bringing seven Lions back into the team.
"We are very respectful of this Scotland team, and are looking forward to what should be a great opening match."
— Welsh Rugby Union (@WelshRugbyUnion) November 1, 2018
Wales team to play Scotland
Forwards: 1 Nicky Smith, 2 Ken Owens, 3 Dillon Lewis, 4 Cory Hill, 5 Alun Wyn Jones (Captain), 6 Dan Lydiate, 7 Justin Tipuric, 8 Ross Moriarty
Backs: 9 Gareth Davies, 10 Gareth Anscombe, 11 Luke Morgan*, 12 Hadleigh Parkes, 13 Jonathan Davies, 14 George North, 15 Leigh Halfpenny
Replacements: 16 Elliot Dee, 17 Rob Evans, 18 Leon Brown, 19 Adam Beard, 20 Aaron Wainwright, 21 Tomos Williams, 22 Jarrod Evans*, 23 Steff Evans
* Denotes uncapped player