Tom Jordan will make his first start for Scotland against South Africa at Murrayfield on Sunday.
The versatile New Zealand-born back, who made his debut as a replacement against Fiji last Saturday after qualifying on residency grounds, has been selected at full-back in place of his injured Glasgow colleague Kyle Rowe as one of four changes to the starting XV.
Toulouse’s Blair Kinghorn, Toulon scrum-half Ben White and Bath stand-off Finn Russell – all of whom were unavailable last weekend as the match took place outside the international window – are the three others added to Gregor Townsend’s side for the visit of the world champions.
Kinghorn, Scotland’s regular full-back, will start on the wing in place of Darcy Graham, who drops out with a head injury. White and Russell take over from last weekend’s half-back pairing of Ali Price and Adam Hastings, who both miss out entirely.
Former Scotland captain Jamie Ritchie is included among the substitutes after being a notable omission from the matchday 23 against Fiji.
Townsend has opted for a 6-2 bench, with Dylan Richardson, Rory Sutherland, Elliot Millar-Mills, Max Williamson and Josh Bayliss the other forwards, and Jamie Dobie and Stafford McDowall the two backs.
Scotland team to play South Africa
Forwards: 1 Pierre Schoeman (Edinburgh Rugby), 2 Ewan Ashman (Edinburgh Rugby), 3 Zander Fagerson (Glasgow Warriors), 4 Grant Gilchrist (Edinburgh Rugby), 5 Scott Cummings (Glasgow Warriors), 6 Matt Fagerson (Glasgow Warriors), 7 Rory Darge (Glasgow Warriors), 8 Jack Dempsey (Glasgow Warriors)
Backs: 9 Ben White (Toulon), 10 Finn Russell (Bath Rugby), 11 Duhan van der Merwe (Edinburgh Rugby), 12 Sione Tuipulotu (Captain, Glasgow Warriors), 13 Huw Jones (Glasgow Warriors), 14 Blair Kinghorn (Toulouse), 15 Tom Jordan (Glasgow Warriors)
Replacements: 16 Dylan Richardson (The Sharks), 17 Rory Sutherland (Glasgow Warriors), 18 Elliot Millar Mills (Northampton Saints), 19 Max Williamson (Glasgow Warriors), 20 Josh Bayliss (Bath Rugby), 21 Jamie Ritchie (Edinburgh Rugby), 22 Jamie Dobie (Glasgow Warriors), 23 Stafford McDowall (Glasgow Warriors)